KMID : 0624620210540010021
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BMB Reports 2021 Volume.54 No. 1 p.21 ~ p.30
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Cancer immunotherapy with T-cell targeting cytokines: IL-2 and IL-7
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Kim Ji-Hae
Lee Kun-Joo Lee Seung-Woo
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Abstract
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Clinical trials have demonstrated that an increased number of effector cells, especially tumor-specific T cells, is positively linked with patients¡¯ prognosis. Although the discovery of checkpoint inhibitors (CPIs) has led to encouraging progress in cancer immunotherapy, the lack of either T cells or targets for CPIs is a limitation for patients with poor prognosis. Since interleukin (IL)-2 and IL-7 are cytokines that target many aspects of T-cell responses, they have been used to treat cancers. In this review, we focus on the basic biology of how these cytokines regulate T-cell response and on the clinical trials using the cytokines against cancer. Further, we introduce several recent studies that aim to improve cytokines¡¯ biological activities and find the strategy for combination with other therapeutics.
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KEYWORD
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Cancer immunotherapy, Cytokine, IL-2, IL-7, T cells
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